Parmi Patel and Jigna Shah* Pages 73-82 (10)
Method: Extensive review of literature was conducted from electronic databases such as Medline and EMBASE and other bibliographies. The database was searched for articles from 1974-2017 using search terms "nanomedicines, toxicological assessment, and physicochemical parameters." Various regulatory websites (USFDA, EMA, MHRA, NANoREG, NNI) were also referred regarding the current updates on regulatory framework for nanomedicine.
Results: Over 200 articles were identified and referred from which relevant data was selected to be included in the current review. The outcome of the review suggests the presence of existing gaps in the knowledge of toxicity assessment of nanomedicines and it also defines specific areas which should be addressed in the near future.
Conclusion: While nanotechnology has gained immense popularity in the research industry due to its improved efficacy compared to traditional counterparts, toxicological considerations and their regulations need to be elucidated. A strategic approach towards toxicological assessment of nanomedicine within the standard set of framework will not only motivate more research on the technology but it will also stir up the conventional drug delivery system.
Nanomedicine, nanoparticles, toxicity, toxicological assessment, physicochemical, parameters, regulatory.
Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujrat, 382481, Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujrat, 382481