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The Role of N-Acetylcysteine in Platelet Aggregation and Reperfusion Injury in Recent Years

[ Vol. 12 , Issue. 2 ]

Author(s):

Mohammadreza Nikbakht, Farhad Ahmadi, Golnaz Vaseghi, Azita Hajhossein Talasaz, Azadeh Eshraghi*, Jamal Naderi and Mohammad A. Daneshmehr Pages 83-91 (9)

Abstract:


Background: N-acetylcysteine (NAC) is an amino acid that contains a cysteine group and is currently used widely in various fields of medical research especially in cardiology. In this review, potential benefits of NAC in the aggregation of platelet and reperfusion injury are evaluated.

Methods: The available evidence was collected by searching Scopus, Pub-Med, Medline, Cochrane central register of controlled trials, and Cochrane database systematic reviews. Our searching was performed without time limitation and only English language articles were included in this review. Key words used as search terms included “N-acetylcysteine”, “platelet aggregation”, “reperfusion injury”.

Results: Over the past decade, several investigations were carried out to ascertain reperfusion injury and antiplatelet properties of NAC, and in this article the results of investigations in both models (human and animal) were addressed in detail. The results revealed that NAC has an important antiplatelet property in animal models while this effect is not very significant in human models and needs more investigations. However, its reperfusion injury in both models is worth noticing.

Conclusion: Due to the limited data about effectiveness of NAC in both human and animal as antiplatelet agent, more investigation is needed to evaluate NAC efficacy in platelet aggregation and reperfusion injury especially in human studies in the future.

Keywords:

NAC, antiplatelet agent, cardiology, platelet aggregation, reperfusion injury, ischemic reperfusion injury, myocardial infarction.

Affiliation:

Department of Pharmacology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Department of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Department of Clinical Pharmacy, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Department of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran

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