Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Stephen L. Atkin, Muhammed Majeed and Amirhossein Sahebkar* Pages 253-258 (6)
Method: A double blind randomised control trial comparing curcumin 1000mg with 10mg of piperine daily to placebo over a 12 week period. 118 patients with type 2 diabetes were recruited out of which 50 control and 50 active subjects completed the trial. Adiponectin, leptin, ghrelin and tumor necrosis factor-α (TNF-α) were measured at baseline and 12 weeks.
Results: Between group comparison of the magnitude of changes showed serum levels of leptin (p<0.001), TNF-α (p<0.001) and leptin:adiponectin ratio (p<0.001) to be significantly reduced while serum adiponectin levels were elevated in the curcuminoids versus placebo group (p=0.032). Changes in serum ghrelin levels did not differ between the study groups (p=0.135).
Conclusion: Curcumin supplementation increased adiponectin, whilst the the leptin:adiponectin ratio (a measure of atherosclerosis) and leptin levels were decreased independent of weight change and reflected a decrease in the inflammatory TNF-α levels.
Adipose tissue, cytokine, turmeric, clinical trial, ghrelin levels, leptin.
Pharmacotherapy Department, School of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Department of Endocrinology, Baqiyatallah University of Medical Sciences, Tehran, Department of Pharmacotherapy, School of Pharmacy, Shiraz University of Medical Sciences, P.O. Box: 1583, Shiraz, Department of Pharmacotherapy, School of Pharmacy, Shiraz University of Medical Sciences, P.O. Box: 1583, Shiraz, Weill Cornell Medicine Qatar, Doha, Sabinsa Corporation, East Windsor, NJ, Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad