Dinesh Puri*, Anil Bhandari, Praveen Kumar Gaur, Mohammad Yasir, S. Sadish Kumar, Deepak Choudhary and Prasoon Kumar Saxena Pages 128-135 (8)
Method: The tablets were formulated by wet granulation technique using three different superdisintegrants (croscarmillose, crospovidone and sodium starch glycolate) at three different levels. The tablets were evaluated for various physical properties like hardness, friability weight variation etc. and various mechanical properties like disintegration time, wetting time to select the best superdisintegrant. The selected superdisintegrant was further used as intra as well as extra granulating agent to develop fast disintegrating tablets of Fagonia schweinfurthii Hadidi dried extract. The optimized formulation was subjected to stability study as per the ICH guidelines. Finally, Ex-vivo antihistaminic study was conducted on guinea pig ileum for optimized formulation and compared with marketed tablet containing cetrizine HCl as API (Stanhist-10, Ranbaxy, Pvt. Ltd).
Results: Physical properties of all tablet batches were found to be acceptable and comply with various official specifications. The disintegration time and wetting time of optimized formulation (F’3) were found to be 1.15±0.08 and 0.56±0.04 min respectively. Results of Ex-vivo study showed a comparable histamine inhibition between optimized tablet (15%) and marketed tablet formulation (18.8%) in a dose of 5 µg/ml.
Conclusion: On the basis of in-vitro and Ex-vivo studies, it was concluded that prepared herbal fast disintegrating tablets were stable and had potent antihistaminic activity.
Antihistaminic activity, croscarmillose, fast disintegrating tablets, herbal formulation, Fagonia species, friability weight variation.
I.T.S College of Pharmacy, Murad Nagar, Ghaziabad (U.P.), Faluty of Pharmacy, Jai Narayan Vyas University, Jodhpur, Rajathan, I.T.S College of Pharmacy, Murad Nagar, Ghaziabad (U.P.), Department of Pharmacy, College of Health and Science, Arsi University, Asella, I.T.S College of Pharmacy, Murad Nagar, Ghaziabad (U.P.), Department of Pharmaceutical Sciences, Mohan Lal Sukhadia University, Udaipur, Rajasthan, I.T.S College of Pharmacy, Murad Nagar, Ghaziabad (U.P.)