Javad Akhtari, Alireza Tafazoli, Hassan Mehrad-Majd and Abdolkarim Mahrooz* Pages 173-182 (10)
Objective: Here, the authors reviewed and highlighted the recent advances in this exciting and fast growing field to help in the development of effective therapeutic tools in controlling human diseases.
Methods: A literature search was conducted from electronic databases such as Pubmed and Google scholar including original articles and review articles.
Conclusion: siRNA delivery systems potentially may be used in future medicine, particularly for untreatable or poorly treated diseases. As we learn more about these delivery systems, we can better use the tremendous opportunities provided by siRNA-based therapeutics. The results of ongoing clinical trials will play an important role in determining whether siRNA-based drugs can be considered as a new class of drugs.
Small interfering RNA, siRNA, drug delivery system, RNA interference, nanotechnology, pharmacogenomics.
Immunogenetics Research Center, Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari