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Comparative Effectiveness of Agmatine and Choline Treatment in Rats with Cognitive Impairment Induced by AlCl3 and Forced Swim Stress

[ Vol. 14 , Issue. ]

Author(s):

Hira Rafi*, Fahad Ahmad, Javaria Anis, Ruba Khan, Hamna Rafiq and Muhammad Farhan Pages 1-14 (14)

Abstract:


Aim: Endogenous agmatine has a significant role in learning and memory process as a neurotransmitter. Various studies described the physiological role of endogenous agmatine in learning and memory of multiple cognitive tasks suggesting elevated levels of agmatine during learning process in rat brain. Dietary intake of choline shown correlation with cognitive functions in human subjects and treatment with choline supplements validated the ability to diminish learning and cognitive impairment dementias.

Method: 36 rats were equally divided into three groups each that received the following treatments: a. water was given orally to control group b. Agmatine (p.o.) 100 mg/Kg/Body Weight and c. Choline (p.o.) 100 mg/Kg/Body Weight daily for 14 days. Behaviors were assessed in Light/Dark Box, Open Field, Novel Object Recognition Test (NOR), T Maze Test and Morris Water Maze Test.

Results: Animals administered with agmatine demonstrated increased time spent in bright area of light/dark box and square crossed while improved spatial memory in Morris water maze and T maze test and enhanced discrimination of novel object in NOR were observed in learning and memory paradigms as compared with choline supplement.

Conclusion: Present study determines that agmatine treatment at the dose of (100 mg/kg/BW) attenuate memory and cognitive impairment that leads to behavioral disorders and deficits in comparison with choline supplements.

Keywords:

Agmatine, Choline, Learning and memory, cognitive impairment, Morris water maze test

Affiliation:

Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi



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