Roberto Lozano*, Alberto Frutos and Alejandro Martinez Pages 1-4 (4)
Objective: Because of this, we aimed to construct a linear-regression model based on the area-under-curve of the victim drugs and the therapeutic range, for a set of known inhibitors of the CYP2D6 of interest.
Methods: Correlation analysis of linear log-log regression of two main variables: the area-under-curve ratio (AUCr) of the victim drugs and of the therapeutic range-to-inhibition constant ratio, with data obtained from literature. Results: Data were fitted to a linear log-log regression, between the average of the AUCr values and the mean value of the therapeutic range-to-inhibition constant ratio (TRm-to-Ki), of the inhibitory drugs.
Conclusions: According to our results, knowledge of the inhibition constant and therapeutic range (or its plasma levels if disponible) of the inhibitor would be sufficient to determine the intensity and clinical relevance of a CYP2D6-mediated DDI.
drug-drug interactions, cytochrome p-450, pharmacokinetics, clinical pharmacology, area-under-curve, inhibition constant, therapeutic range.
Pharmacy Department.Hospital Nuestra Señora de Gracia, Zaragoza, Pharmacy Department, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Pharmacy Department , Centro de Reahabilitación Psicosocial de “Nuestra Señora del Pilar”, Zaragoza