Nasr Alrabadi*, Iyad S. Albustami, Husam A. Abuhayyeh, Khaled M. El-Muwalla, Rama J. Alawneh, Laith N. AL-Eitan, Karem H. Alzoubi, Majed Masadeh, Omar F. Khabour and Razan Haddad Pages 1-11 (11)
Methods: A PubMed and Google Scholar literature search was obtained on both pre-clinical and clinical studies related to CA and H.pylori infection.
Results: Available clinical studies showed improvement in the eradication of H. pylori by about 10-20% when CA was added to the treatment regimens. This effect for CA could be related to several mechanisms including inhibition of H. pylori growth by binding to penicillin-binding proteins (PBPs), the transformation of H. pylori from the active filamentous form into coccoidal form, induction of the release of dopamine, modulation of immunological response towards H. pylori infection and its relationship with other microbiota. Randomized-controlled studies on patients with resistance H. pylori are needed. Moreover, In_vitro studies to evaluate the mechanisms by which CA may influence H. pylori are warranted.
Conclusion: The presented literature suggests potential avenues for the use of CA in the management of peptic ulcer disease and H.pylori infection.
Clavulanic acid, Clauvanate, Helicobacter pylori, Eradication therapy, Peptic ulcer disease, Gastric cancer.
Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Department of Applied Biological Sciences, Faculty of Science, Jordan University of Science and Technology, Irbid, Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Department of Medical Laboratory Sciences, Faculty of Medical Sciences, Jordan University of Science and Technology, Irbid, Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid