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SLCO1B1 Gene Polymorphisms (rs2306283 and rs4149056) and Statin-Induced Myopathy in Jordanian Diabetics

[ Vol. 15 , Issue. ]

Author(s):

Zaineh M. Shahrure, Yacoub M. Irshaid*, Khader N. Mustafa, Mousa A. Abujbara, Mohammad Al Shhab, Mohammed S. El-Khateeb and Kamel M. Ajlouni Pages 1-8 (8)

Abstract:


Background: The use of statins to lower high serum cholesterol levels may be associated with a number of adverse reactions, including severe myopathy. The solute carrier organic anion transporter 1B1 (SLCO1B1) gene, which encodes the organic anion-transporting polypeptide OATP1B1 is related to the intracellular transport of statins. The aim of this research is to study the association of rs2306283 and rs4149056 genetic polymorphism of SLCO1B1 gene with the development of statin-induced myopathy in Jordanian diabetics receiving statins.

Methods: We included 413 patients attending the Diabetes Clinics of the National Center for Diabetes, Endocrinology and Genetics), Amman, Jordan. The study was approved by the Institutional Review Board of NCDEG. Myopathy was defined as elevation of creatine kinase more than 3 times the upper limit of normal. Every subject signed an informed consent form and donated 3-5 mL of venous blood. Genome DNA was extracted from lymphocytes of peripheral blood. Genotypes were identified using Tetra Amplification Refractory Mutation System of SLCO1B1.

Results: The minor allele frequencies of rs2306283 [G] and rs4149056 [C] were 0.38 and 0.23, respectively. The two SNPs followed the Hardy-Weinberg equilibrium. The development of SIM was significantly associated with the homozygous and heterozygous minor allele genotype of rs4149056 (CC and CT), and the homozygous wild type allele genotype of rs2306283 (AA). There was no linkage disequilibrium between the two SNPs the studied subgroups.

Conclusions: Genetic polymorphism in the SLCO1B1 Gene is a risk factor for the development of SIM in Jordanian patients.

Keywords:

Jordanian diabetics, Myopathy, rs4149056, rs23006283, SLCO1B1 polymorphism, statins.

Affiliation:

Department of Pharmacology, The University of Jordan, Department of Pharmacology, The University of Jordan, Department of Internal Medicine, College of Medicine, the University of Jordan, The National Center for Diabetes, Endocrinology, and Genetics, Amman 11942, Department of Pharmacology, The University of Jordan, The National Center for Diabetes, Endocrinology, and Genetics, Amman 11942, The National Center for Diabetes, Endocrinology, and Genetics, Amman 11942



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