Anti-drug Antibodies Monitoring in Biologics Use: Clinical Implications

Author(s):

Rim Dhahri*, Selma Athimni, Maroua Slouma, Leila Metoui, Imene Gharsallah and Bassem Louzir Pages 1-4 (4)

Abstract:

Background: Over the years, drug monitoring-such as anti drug antibodies (ADA) dosage- has witnessed major transformations. In fact ADA are more and more used in rheumatology and gastro-enterology in monitoring chronic inflammatory diseases therapeutic response. The main purpose of those researches is to produce less immunogenic drug and in consequences to improve tolerance and efficiency, since immunogenicity of those drugs still is the main constraint to their long-term use. The aim of this review was to highlight anti-drug-antibodies potential effects on the pharmacokinetics and bioavailability of biotherapies as well as their clinical implications.

Methods: For this purpose we did collect and summarize published data on pubmed using key words “Biologics, Rheumatoid Arthritis, Spondyloarthritis, Crohn disease, Anti drug antibodies, residual rate, immunogenicity, efficacy, tolerance”. The time-period selected for this study was 2000-2019.

Results: Anti- Drug-antibodies do decrease pharmaco-availability of drugs and in consequences its efficiency and high risk of refractory disease and side effects.

Conclusion: Recent literature is consistent with the fact that drug monitoring using ADA dosage coupled with residual drug concentration offers reliable options to comfort practitioner’ therapeutic management decisions. This is particularly interesting in failure to treatment or in side effects onset situations.

Keywords:

Anti drug antibodies, biologics, residual dose, spondyloarthritis, rheumatoid arthritis, crohn disease

Affiliation:

Rheumatology Department, Military Hospital of Tunis, Rheumatology Department, Military Hospital of Tunis, Rheumatology Department, Military Hospital of Tunis, Rheumatology Department, Military Hospital of Tunis, Rheumatology Department, Military Hospital of Tunis, Internal Medicine Department, Military Hospital of Tunis

Read Full-Text article