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Pharmacologic Evidence of Green Tea in Targeting Tyrosine Kinases

[ Vol. 15 , Issue. ]

Author(s):

Joyce T.S. Li, Kam L. Hon*, Alexander K.C. Leung and Vivian W.Y. Lee Pages 1-8 (8)

Abstract:


Background: Green tea has been extensively studied for its potential health benefits against diseases, such as cancers, cognitive degenerative diseases, and cardiovascular diseases.

Methods: The authors undertook a structured search of peer-reviewed research articles from three databases including PubMed, Embase, and Ovid MEDLINE. Recent and up-to-date studies relevant to the topic were included.

Results: Green tea extract exerts its functions through interacting with multiple signalling pathways in human cells. Protein tyrosine kinase is one of the examples. Abnormal activation of tyrosine kinase is observed in some tumour cells. Green tea extract inhibits phosphorylation, reduces expression, or attenuates downstream signalling of epidermal growth factor receptor, insulin-like growth factor receptor, vascular endothelial growth factor receptor, and non-receptor tyrosine kinase. Combination of green tea extract with tyrosine kinase inhibitors may provide synergistic effects by overcoming acquired resistance.

Conclusion: Green tea extract can affect multiple receptor targets. In the current review, we discuss the pharmacological mechanisms of green tea on tyrosine kinases and their implications on common diseases.

Keywords:

Cancer, green tea, tyrosine kinase, targeted therapy

Affiliation:

Centre for Learning Enhancement and Research, The Chinese University of Hong Kong. 5/F, Hui Yeung Shing Building, The Chinese University of Hong Kong, Shatin, Department of Paediatrics, The Chinese University of Hong Kong; 6/F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Department of Pediatrics, The University of Calgary, Alberta Children’s Hospital, Calgary, Alberta, Centre for Learning Enhancement and Research, The Chinese University of Hong Kong. 5/F, Hui Yeung Shing Building, The Chinese University of Hong Kong, Shatin



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